Jed Whedon worked mostly as a composer for video game soundtracks before collaborating with his brother Joss Whedon and his then-fiancée (now wife) Maurissa Tancharoen on Dr. Horrible's Sing-Along Blog, where he contributed the main theme and other songs. He and Tancharoen also created the online series Apartment 4B.
Whedon and Tancharoen have (co-)written the following episodes:
- Jed Whedon and Maurissa Tancharoen wrote the song "Remains", which Tancharoen sang. It plays at the end of "Epitaph One". He also wrote and performed the song "Drones", which plays in "Belonging".
- Jed Whedon makes a cameo appearance in "Epitaph Two: Return" during the kitchen table scene.